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Rockefeller University Press

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

Overview of attention for article published in The Journal of Experimental Medicine, February 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 11,631)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
101 news outlets
blogs
9 blogs
twitter
190 X users
facebook
16 Facebook pages
wikipedia
2 Wikipedia pages
googleplus
11 Google+ users
reddit
3 Redditors
video
1 YouTube creator

Citations

dimensions_citation
98 Dimensions

Readers on

mendeley
188 Mendeley
citeulike
1 CiteULike
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Title
BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions
Published in
The Journal of Experimental Medicine, February 2018
DOI 10.1084/jem.20171831
Pubmed ID
Authors

Xiangyou Hu, Brati Das, Hailong Hou, Wanxia He, Riqiang Yan

Abstract

BACE1 initiates the generation of the β-amyloid peptide, which likely causes Alzheimer's disease (AD) when accumulated abnormally. BACE1 inhibitory drugs are currently being developed to treat AD patients. To mimic BACE1 inhibition in adults, we generated BACE1 conditional knockout (BACE1fl/fl) mice and bred BACE1fl/flmice with ubiquitin-CreERmice to induce deletion of BACE1 after passing early developmental stages. Strikingly, sequential and increased deletion of BACE1 in an adult AD mouse model (5xFAD) was capable of completely reversing amyloid deposition. This reversal in amyloid deposition also resulted in significant improvement in gliosis and neuritic dystrophy. Moreover, synaptic functions, as determined by long-term potentiation and contextual fear conditioning experiments, were significantly improved, correlating with the reversal of amyloid plaques. Our results demonstrate that sustained and increasing BACE1 inhibition in adults can reverse amyloid deposition in an AD mouse model, and this observation will help to provide guidance for the proper use of BACE1 inhibitors in human patients.

X Demographics

X Demographics

The data shown below were collected from the profiles of 190 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 188 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 35 19%
Student > Ph. D. Student 28 15%
Student > Bachelor 28 15%
Student > Master 25 13%
Student > Postgraduate 10 5%
Other 25 13%
Unknown 37 20%
Readers by discipline Count As %
Neuroscience 36 19%
Biochemistry, Genetics and Molecular Biology 33 18%
Agricultural and Biological Sciences 22 12%
Medicine and Dentistry 17 9%
Pharmacology, Toxicology and Pharmaceutical Science 7 4%
Other 30 16%
Unknown 43 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 981. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2020.
All research outputs
#16,791
of 25,579,912 outputs
Outputs from The Journal of Experimental Medicine
#9
of 11,631 outputs
Outputs of similar age
#368
of 456,578 outputs
Outputs of similar age from The Journal of Experimental Medicine
#2
of 60 outputs
Altmetric has tracked 25,579,912 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,631 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 456,578 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.