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Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis

Overview of attention for article published in The Journal of Experimental Medicine, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
7 news outlets
twitter
38 tweeters
facebook
7 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
95 Dimensions

Readers on

mendeley
121 Mendeley
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Title
Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis
Published in
The Journal of Experimental Medicine, June 2016
DOI 10.1084/jem.20151255
Pubmed ID
Authors

Dao Xuan Nguyen, Michael R. Ehrenstein

Abstract

The interplay between inflammatory and regulatory pathways orchestrates an effective immune response that provides protection from pathogens while limiting injury to host tissue. Tumor necrosis factor (TNF) is a pivotal inflammatory cytokine, but there is conflicting evidence as to whether it boosts or inhibits regulatory T cells (T reg cells). In this study, we show that the therapeutic anti-TNF antibody adalimumab, but not the soluble TNF receptor etanercept, paradoxically promoted the interaction between monocytes and T reg cells isolated from patients with rheumatoid arthritis (RA). Adalimumab bound to monocyte membrane TNF from RA patients and unexpectedly enhanced its expression and its binding to TNF-RII expressed on T reg cells. As a consequence, adalimumab expanded functional Foxp3(+) T reg cells equipped to suppress Th17 cells through an IL-2/STAT5-dependent mechanism. Our data not only highlight the beneficial effect of membrane TNF on T reg cell numbers during chronic inflammation, but in addition reveal how a therapeutic antibody that is thought to act by simply blocking its target can enhance the regulatory properties of this proinflammatory cytokine.

Twitter Demographics

The data shown below were collected from the profiles of 38 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 121 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 22%
Researcher 19 16%
Student > Bachelor 15 12%
Other 13 11%
Student > Master 13 11%
Other 19 16%
Unknown 15 12%
Readers by discipline Count As %
Immunology and Microbiology 33 27%
Medicine and Dentistry 18 15%
Biochemistry, Genetics and Molecular Biology 16 13%
Agricultural and Biological Sciences 14 12%
Pharmacology, Toxicology and Pharmaceutical Science 10 8%
Other 13 11%
Unknown 17 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 71. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2019.
All research outputs
#350,608
of 17,186,405 outputs
Outputs from The Journal of Experimental Medicine
#232
of 10,385 outputs
Outputs of similar age
#9,149
of 272,008 outputs
Outputs of similar age from The Journal of Experimental Medicine
#6
of 51 outputs
Altmetric has tracked 17,186,405 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,385 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,008 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.